Company Information

Company Profile

Company Profile

Adaptimmune is a leader in TCR T-cell therapy, focused on developing novel cancer immunotherapy products. We utilize the body’s own machinery – the T-cell – to target and destroy cancer cells by increasing the affinity of naturally occurring T-cell receptors (TCRs). We have developed a proprietary T-cell receptor platform that enables us to identify cancer targets, find and genetically engineer T-cell receptors, or TCRs, and produce TCR therapeutic candidates called SPEAR (Specific Peptide Enhanced Affinity Receptor) T-cells that recognize these targets on cancer cells. We engineer a patient’s own T-cells to express our SPEAR TCRs to target and potentially destroy tumors.

Our wholly-owned pipeline includes SPEAR T-cell therapies targeting ADP-A2M10 (MAGE-A10), ADP-A2M4 (MAGE-A4), and ADP-A2AFP (AFP), which are being investigated in clinical studies across multiple solid tumor indications. We continue to build a pipeline of further proprietary TCR therapeutic candidates, second generation treatment options, as well as allogeneic (off-the-shelf) solutions.

We believe our approach will lead to SPEAR T-cells with the potential to significantly impact cancer treatment and the clinical outcomes of cancer patients.

Industry Classifications

Sector

Healthcare

Industry

Biotechnology

SIC

Pharmaceutical Preparations (2834)

Adaptimmune at a Glance

5

Responses in five solid tumor indications demonstrate SPEAR T-cell potential to treat cancer.

2022

The Company aims to launch ADP‑A2M4 for sarcoma in 2022.

$50M

Through a co-development and co-commercialization agreement with Astellas, the Company has received an upfront payment of $50 million and is entitled to receive research funding of up to $7.5 million per year.

As of Dec. 31, 2019 • Q4 2019 Press Release

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