EXHIBIT 1
 
JOINT FILING AGREEMENT
 
The undersigned hereby agree that the Statement on this Schedule 13D, dated November 18, 2015 (the “Schedule 13D”), with respect to the ordinary shares of Adaptimmune Therapeutics plc is filed, and all amendments thereto will be filed, on behalf of each of us pursuant to and in accordance with the provisions of Rule 13d-1(k) under the Securities and Exchange Act of 1934, as amended, and that this Agreement shall be included as an Exhibit to this Schedule 13D.  Each of the undersigned agrees to be responsible for the timely filing of the Schedule 13D, and for the completeness and accuracy of the information concerning itself contained therein.  This Agreement may be executed in any number of counterparts, all of which taken together shall constitute one and the same instrument.
 
IN WITNESS WHEREOF, the undersigned have executed this Agreement as of the 18th day of November, 2015.
 
 
OrbiMed Advisors LLC
a Delaware Limited Liability Company
       
       
 
By:
  /s/ Samuel D. Isaly  
   
Name:
Samuel D. Isaly
 
   
Title:
Managing Member
 
         
         
 
OrbiMed Capital GP V LLC
a Delaware Limited Liability Company
 
 
By:
OrbiMed Advisors LLC
A Delaware Limited Liability Company
and its Managing Member
     
       
 
By:
  /s/ Samuel D. Isaly  
   
Name:
Samuel D. Isaly
 
   
Title:
Managing Member
 
       
       
       
 
Samuel D. Isaly
 
     
       
 
By:
 /s/ Samuel D. Isaly  
   
Samuel D. Isaly