With a research base in Oxford, UK and a clinical base in Philadelphia, US, Adaptimmune is focused on the use of T cell therapy to treat cancer. It aims to utilise the body’s own machinery – the T cell – to target and destroy cancerous by using engineered, increased affinity T cell receptors (TCRs) as a means of strengthening natural patient T cell responses. Adaptimmune undertakes all of its own research and development using proprietary T cell receptor engineering technology co-owned with Immunocore Ltd (formerly Avidex/MediGene) and exclusively licensed for T cell therapy. Adaptimmune is now in the clinic in the US, in multiple cancer indications with its engineered TCR to the NY-ESO-1 cancer testis antigen.
Adaptimmune’s Mission Statement
The Company’s core technology is the development of affinity-enhanced T cell receptors (TCRs) for use in autologous T cell therapy.
The Adaptimmune product candidate is a T cell expressing an engineered TCR to recognize a tumour antigen or peptide associated with a HLA molecule.