Annual report pursuant to Section 13 and 15(d)

Summary of Significant Accounting Policies - Research and Development Expenditure (Details)

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Summary of Significant Accounting Policies - Research and Development Expenditure (Details) - USD ($)
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Summary of Significant Accounting Policies      
Acquired in-process R&D expensed $ 562,000 $ 889,000 $ 4,556,000
Reimbursement of Research and Development Tax and Expenditure Credit $ 34,082,000 $ 19,442,000 $ 18,649,000