Annual report pursuant to Section 13 and 15(d)

Contingencies and commitments - Clinical Trials and Contract Manufacturing Commitments (Details)

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Contingencies and commitments - Clinical Trials and Contract Manufacturing Commitments (Details) - Clinical trials and contract manufacturing commitments - USD ($)
$ in Thousands
6 Months Ended 12 Months Ended
Dec. 31, 2015
Dec. 31, 2017
Dec. 31, 2016
Jun. 30, 2015
Contingencies and commitments        
Other commitments   $ 76,725    
Other commitments, due within one year   33,028    
Other commitments, due in one to three years   41,214    
Other commitments, due in three to five years   1,475    
Other commitments, due after five years   1,008    
Subcontract costs $ 8,585 $ 41,505 $ 23,565 $ 8,818