Quarterly report pursuant to Section 13 or 15(d)

Selected historical financial information - Consolidated Balance Sheet (Details)

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Selected historical financial information - Consolidated Balance Sheet (Details) - USD ($)
$ in Thousands
Mar. 31, 2016
Dec. 31, 2015
Jun. 30, 2015
Mar. 31, 2015
Dec. 31, 2014
Current assets          
Cash and cash equivalents $ 163,766 $ 194,263 $ 229,046 $ 92,599 $ 101,664
Short-term Bank Deposits 62,337 54,620 55,292    
Accounts receivable, net of allowance for doubtful accounts of $- and $- 1 744 4    
Other current assets and prepaid expenses (including current portion of clinical materials) 12,457 13,420 10,740    
Total current assets 238,561 263,047 295,082    
Restricted cash 4,413 4,508      
Clinical materials 3,601 4,736      
Property, plant and equipment, net 13,845 13,225 5,571    
Intangibles, net 1,140 305      
Total assets 261,560 285,821 300,653    
Current liabilities          
Accounts payable 2,440 7,884 1,982    
Accrued expenses and other accrued liabilities 5,321 7,518 3,877    
Deferred revenue 12,077 12,487 20,906    
Total current liabilities 19,838 27,889 26,765    
Deferred revenue, less current portion 22,776 22,939 14,885    
Total liabilities 42,614 50,828 41,650    
Equity          
Common stock - Ordinary shares par value GBP 0.001 682 682 682    
Additional paid in capital 334,437 332,363 328,795    
Accumulated other comprehensive loss (10,684) (8,139) (3,561)    
Accumulated deficit (105,489) (89,913) (66,913)    
Total equity 218,946 234,993 259,003    
Total liabilities and stockholders' equity $ 261,560 $ 285,821 $ 300,653