Annual report pursuant to Section 13 and 15(d)

Summary of Significant Accounting Policies - Research and Development Expenditure (Details)

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Summary of Significant Accounting Policies - Research and Development Expenditure (Details) - USD ($)
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Summary of Significant Accounting Policies      
Acquired in-process R&D expensed $ 210,000 $ 1,003,000 $ 3,000,000
Grant income   150,000 414,000
Reimbursement of Research and Development Tax and Expenditure Credit $ 17,299,000 $ 10,576,000 $ 6,891,000