Quarterly report pursuant to Section 13 or 15(d)

Stockholders' equity - Underwritten public offering and Registered direct offering (Details)

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Stockholders' equity - Underwritten public offering and Registered direct offering (Details) - USD ($)
3 Months Ended 6 Months Ended 9 Months Ended
Aug. 10, 2021
Sep. 30, 2021
Jun. 30, 2020
Mar. 31, 2020
Jun. 30, 2021
Sep. 30, 2021
Sep. 30, 2020
Stockholders' equity              
Issue of shares under At The Market sales agreement, net of commission and expenses   $ 2,519,000          
Remaining amount under the Sales Agreement           $ 197,360,000  
Proceeds from issuance of common stock from offerings, net of commissions and issuance costs           $ 2,529,000 $ 334,388,000
Common stock              
Stockholders' equity              
Issue of shares under At The Market sales agreement, net of commission and expenses   $ 4,000          
Issue of shares under At The Market sales agreement, net of commission and expenses, shares   3,069,330          
Issuance of common stock (in shares)   3,069,330 141,450,000 144,900,000      
American Depository Shares (ADSs)              
Stockholders' equity              
Issue of shares under At The Market sales agreement, net of commission and expenses, shares   511,555          
Proceeds from issuance of common stock from offerings, net of commissions and issuance costs         $ 2,519,000    
Maximum | American Depository Shares (ADSs)              
Stockholders' equity              
Issue of shares under At The Market sales agreement, net of commission and expenses $ 200,000,000