Annual report pursuant to Section 13 and 15(d)
Cover
Document and Entity Information
Financial Statements
CONSOLIDATED BALANCE SHEETS
CONSOLIDATED BALANCE SHEETS (Parenthetical)
CONSOLIDATED STATEMENTS OF OPERATIONS
CONSOLIDATED STATEMENTS OF OPERATIONS (Parenthetical)
CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS
CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS (Parenthetical)
CONSOLIDATED STATEMENTS OF CHANGES IN EQUITY
CONSOLIDATED STATEMENTS OF CASH FLOWS
Notes to Financial Statements
General
Summary of Significant Accounting Policies
Revenue
Financial instruments
Other current assets
Property, plant and equipment, net
Intangible assets, net
Operating Leases
Accrued expenses and other current liabilities
Contingencies and commitments
Stockholders' equity
Share-based compensation
Income taxes
Geographic information
Accounting Policies
Summary of Significant Accounting Policies (Policies)
Notes Tables
Summary of Significant Accounting Policies (Tables)
Revenue (Tables)
Financial instruments (Tables)
Other current assets (Tables)
Property, plant and equipment, net (Tables)
Intangible assets, net (Tables)
Operating Leases (Tables)
Accrued expenses and other current liabilities (Tables)
Share-based compensation (Tables)
Income taxes (Tables)
Geographic information (Tables)
Notes Details
General (Details)
Summary of Significant Accounting Policies - Foreign currency (Details)
Summary of Significant Accounting Policies - Changes in Accumulated other comprehensive (loss) income (Details)
Summary of Significant Accounting Policies - Reclassification out of Other comprehensive (loss) income (Details)
Summary of Significant Accounting Policies - Cash, cash equivalents and restricted cash (Details)
Summary of Significant Accounting Policies - Available-for-sale debt securities (Details)
Summary of Significant Accounting Policies - Accounts receivable (Details)
Summary of Significant Accounting Policies - Property, plant and equipment (Details)
Summary of Significant Accounting Policies - Intangibles (Details)
Summary of Significant Accounting Policies - Leases (Details)
Summary of Significant Accounting Policies - Segment Reporting (Details)
Summary of Significant Accounting Policies - Research and Development Expenditure (Details)
Summary of Significant Accounting Policies - Retirement Benefits (Details)
Summary of Significant Accounting Policies - Interest income (Details)
Summary of Significant Accounting Policies - Loss per share (Details)
Summary of Significant Accounting Policies - Antidilutive Securities (Details)
Summary of Significant Accounting Policies - Options (Details)
Revenue - Revenue from contracts with customers (Details)
Revenue - Collaboration Agreement - The Astellas Collaboration Agreement (Details)
Revenue - Collaboration Agreement - Performance obligations (Details)
Revenue - Collaboration Agreement - The GSK Collaboration and License Agreement (Details)
Financial instruments - Fair value of assets and liabilities (Details)
Financial instruments - Cash Equivalents and Short-term Deposits (Details)
Financial instruments - Collaboration and License Agreement (Details)
Financial instruments - Foreign Exchange Risk (Details)
Other current assets (Details)
Property, plant and equipment, net - Schedule of Property and Equipment (Details)
Property, plant and equipment, net - Depreciation Expense (Details)
Intangible assets, net - Tabular Disclosure (Details)
Intangible assets, net - Amortization Expense (Details)
Intangible assets, net - Aggregate Amortization Expense (Details)
Operating Leases - Lease Cost (Details)
Operating Leases - Maturities (Details)
Accrued expenses and other current liabilities (Details)
Accrued expenses and other current liabilities - Supply agreement (Details)
Accrued expenses and other current liabilities - Schedule of reserves (Details)
Contingencies and commitments - Capital Commitments (Details)
Contingencies and commitments - Clinical Trials and Contract Manufacturing Commitments (Details)
Contingencies and commitments - Collaborations and License Agreements (Details)
Stockholders' equity - Ordinary Shares (Details)
Stockholders' equity - Underwritten public offering and Registered direct offering (Details)
Share-based compensation - Option Plans (Details)
Share-based compensation - Share-based Compensation Expense (Details)
Share based compensation - Unrecognized Compensation Cost (Details)
Share-based compensation - Options (Details)
Share based compensation - Option Activity (Details)
Share based compensation - Stock Options Outstanding (Details)
Share based compensation - Options Exercised (Details)
Share-based compensation - Fair Value Assumptions (Details)
Income taxes - Loss before Income Taxes (Details)
Income taxes - Components of Income Tax Expense (Benefit) (Details)
Income taxes - Reconciliation of Deferred Tax Assets and Liabilities (Details)
Income taxes - Change in Valuation Allowance (Details)
Income taxes - Reconciliation of Effective Tax Rate (Details)
Income taxes - Tax Rates (Details)
Income taxes - Change in Tax Rate (Details)
Income taxes - Unrecognized Tax Benefits (Details)
Geographic information - Operations by Geographic Area - Long-lived Assets (Details)
Geographic information - Major Customers (Details)
CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS