Annual report pursuant to Section 13 and 15(d)

Summary of Significant Accounting Policies - Leases (Details)

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Summary of Significant Accounting Policies - Leases (Details) - USD ($)
1 Months Ended 12 Months Ended
Jul. 31, 2015
Dec. 31, 2018
Sep. 30, 2015
Lease expense   $ 3,399,000  
Lease for Offices and Research facilities in Philadelphia, U.S.      
Lease term (in years) 15 years    
Early termination option (in months) 123 months    
Lease for Research and development facility in Oxfordshire, U.K.      
Lease term (in years)     25 years