Quarterly report pursuant to Section 13 or 15(d)

Revenue (Details)

v3.5.0.2
Revenue (Details)
$ in Thousands, £ in Millions
1 Months Ended 3 Months Ended 6 Months Ended 12 Months Ended 19 Months Ended
Jun. 30, 2014
GBP (£)
Jun. 30, 2014
USD ($)
Jun. 30, 2016
USD ($)
Jun. 30, 2015
USD ($)
Dec. 31, 2016
USD ($)
Jun. 30, 2016
USD ($)
Milestone
item
Jun. 30, 2015
USD ($)
Dec. 31, 2020
USD ($)
Dec. 31, 2019
USD ($)
Dec. 31, 2018
USD ($)
Dec. 31, 2017
USD ($)
Dec. 31, 2015
GBP (£)
Dec. 31, 2015
USD ($)
Collaboration and License Agreement                          
Revenue recognized     $ 328 $ 2,783   $ 3,246 $ 5,511            
Collaborative arrangement | GlaxoSmithKline Intellectual Property Development Ltd                          
Collaboration and License Agreement                          
Number of additional target peptides, that the entity has right to nominate | item           4              
Upfront payment received £ 25 $ 42,000                      
Milestone payments received                       £ 14 $ 22,000
Number of milestones achieved during the period | Milestone           0              
Revenue recognized     328 $ 2,783   $ 3,246 $ 5,511            
Collaborative arrangement | GlaxoSmithKline Intellectual Property Development Ltd | Change in service delivery period in collaboration and license agreement | Adjustment                          
Collaboration and License Agreement                          
Revenue recognized     $ (2,785)                    
Collaborative arrangement | GlaxoSmithKline Intellectual Property Development Ltd | Change in service delivery period in collaboration and license agreement | Forecast adjustment                          
Collaboration and License Agreement                          
Revenue recognized         $ (672)     $ 1,642 $ 1,187 $ 1,793 $ (1,344)