Quarterly report pursuant to Section 13 or 15(d)

Share-based compensation - Share-based Compensation Expense (Details)

v3.5.0.2
Share-based compensation - Share-based Compensation Expense (Details) - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended
Jun. 30, 2016
Jun. 30, 2015
Jun. 30, 2016
Jun. 30, 2015
Total share-based compensation expense included in the consolidated statements of operations        
Total share-based compensation expense $ 2,439 $ 4,810 $ 4,541 $ 6,292
Research and development        
Total share-based compensation expense included in the consolidated statements of operations        
Total share-based compensation expense 1,376 2,533 2,268 3,500
General and administrative        
Total share-based compensation expense included in the consolidated statements of operations        
Total share-based compensation expense $ 1,063 $ 2,277 $ 2,273 $ 2,792