Quarterly report pursuant to Section 13 or 15(d)

Contingencies and commitments - Clinical Trials and Contract Manufacturing Commitments (Details)

v3.5.0.2
Contingencies and commitments - Clinical Trials and Contract Manufacturing Commitments (Details) - Clinical trials and contract manufacturing commitments - USD ($)
$ in Thousands
3 Months Ended 9 Months Ended
Sep. 30, 2016
Sep. 30, 2015
Sep. 30, 2016
Sep. 30, 2015
Contingencies and commitments        
Other commitments $ 54,611   $ 54,611  
Other commitments, due within one year 25,850   25,850  
Other commitments, due in one to three years 20,292   20,292  
Other commitments, due in three to five years 7,659   7,659  
Other commitments, due after five years 810   810  
Subcontract costs $ 6,032 $ 3,406 $ 15,908 $ 8,040