Quarterly report pursuant to Section 13 or 15(d)

Share-based compensation - Share-based Compensation Expense (Details)

v3.5.0.2
Share-based compensation - Share-based Compensation Expense (Details) - USD ($)
$ in Thousands
3 Months Ended 9 Months Ended
Sep. 30, 2016
Sep. 30, 2015
Sep. 30, 2016
Sep. 30, 2015
Total share-based compensation expense included in the consolidated statements of operations        
Total share-based compensation expense $ 2,286 $ 1,401 $ 6,825 $ 7,694
Research and development        
Total share-based compensation expense included in the consolidated statements of operations        
Total share-based compensation expense 1,170 389 3,438 3,887
General and administrative        
Total share-based compensation expense included in the consolidated statements of operations        
Total share-based compensation expense $ 1,116 $ 1,012 $ 3,387 $ 3,807