Quarterly report pursuant to Section 13 or 15(d)

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS

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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
9 Months Ended
Sep. 30, 2018
Sep. 30, 2017
Cash flows from operating activities    
Net loss $ (59,341,000) $ (42,875,000)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation 5,248,000 3,418,000
Amortization 464,000 267,000
Share-based compensation expense 12,453,000 7,956,000
Realized loss on available-for-sale debt securities 2,473,000  
Unrealized foreign exchange gain (losses) 4,921,000 (6,886,000)
Other 262,000 606,000
Changes in operating assets and liabilities:    
(Increase) decrease in receivables and other operating assets (4,140,000) 4,180,000
Decrease (increase) in non-current operating assets 490,000 (484,000)
(Decrease) increase in payables and deferred revenue (35,533,000) 859,000
Net cash used in operating activities (72,703,000) (32,959,000)
Cash flows from investing activities    
Acquisition of property, plant and equipment (3,823,000) (22,791,000)
Acquisition of intangibles (666,000) (288,000)
Proceeds from disposal of property, plant and equipment   550,000
Maturity of short-term deposits   40,645,000
Investment in short-term deposits   (18,000,000)
Maturity or redemption of marketable securities 114,988,000 7,032,000
Investment in marketable securities (75,545,000) (93,218,000)
Net cash provided by (used in) investing activities 34,954,000 (86,070,000)
Cash flows from financing activities    
Proceeds from issuance of common stock, net of issuance costs $347 and $4,774 99,653,000 103,167,000
Proceeds from exercise of stock options 2,933,000 401,000
Net cash provided by financing activities 102,586,000 103,568,000
Effect of currency exchange rate changes on cash, cash equivalents and restricted cash 4,111,000 2,223,000
Net increase (decrease) in cash, cash equivalents and restricted cash 68,948,000 (13,238,000)
Cash, cash equivalents and restricted cash at start of period 88,296,000 162,796,000
Cash, cash equivalents and restricted cash at end of period $ 157,244,000 $ 149,558,000