Quarterly report pursuant to Section 13 or 15(d)

UNAUDITED CONDENSED CONSOLIDATED BALANCE SHEETS

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UNAUDITED CONDENSED CONSOLIDATED BALANCE SHEETS - USD ($)
$ in Thousands
Mar. 31, 2019
Dec. 31, 2018
Current assets    
Cash and cash equivalents $ 49,917 $ 68,379
Marketable securities - available-for-sale debt securities 118,241 136,755
Accounts receivable, net of allowance for doubtful accounts of $0 and $0   192
Other current assets and prepaid expenses (including current portion of clinical materials) 32,143 25,769
Total current assets 200,301 231,095
Restricted cash 4,473 4,097
Clinical materials 3,972 3,953
Operating lease right-of-use assets, net of accumulated amortization of $656 (2018: $0) 24,462  
Property, plant and equipment, net of accumulated depreciation of $18,083 (2018: $15,924) 35,703 36,118
Intangibles, net of accumulated amortization of $1,411 (2018: $1,218) 1,529 1,473
Total assets 270,440 276,736
Current liabilities    
Accounts payable 5,391 4,083
Operating lease liabilities, current 2,217  
Accrued expenses and other accrued liabilities 15,827 20,354
Total current liabilities 23,435 24,437
Operating lease liabilities, non-current 26,779  
Other liabilities, non-current 571 5,414
Total liabilities 50,785 29,851
Stockholders' equity    
Common stock - Ordinary shares par value ?0.001, 701,103,126 authorized and 628,294,702 issued and outstanding (2018: 701,103,126 authorized and 627,454,270 issued and outstanding) 940 939
Additional paid in capital 577,722 574,208
Accumulated other comprehensive loss (13,096) (9,763)
Accumulated deficit (345,911) (318,499)
Total stockholders' equity 219,655 246,885
Total liabilities and stockholders' equity $ 270,440 $ 276,736