| Share-based compensation | 
 Note 9 — Share-based compensation 
The following table shows the total share-based compensation expense included in the unaudited consolidated statements of operations (in thousands): 
 | 
 | 
 | 
 | 
 | 
 | 
 | 
 | 
 | 
 | 
 | 
 | 
 | 
 | 
 | 
 
  | 
  | 
  | 
Three months ended   | 
  | 
Nine months ended   | 
  | 
 
  | 
  | 
  | 
September 30,   | 
  | 
September 30,   | 
  | 
 
  | 
      | 
2020  | 
      | 
2019  | 
      | 
2020  | 
      | 
2019  | 
  | 
  | 
 
Research and development  | 
  | 
$  | 
 1,219  | 
  | 
$  | 
 144  | 
  | 
$  | 
 3,126  | 
  | 
$  | 
 2,951  | 
  | 
  | 
 
General and administrative  | 
  | 
   | 
 2,061  | 
  | 
   | 
 1,676  | 
  | 
   | 
 4,226  | 
  | 
  | 
 5,544  | 
  | 
  | 
 
  | 
  | 
$  | 
 3,280  | 
  | 
$  | 
 1,820  | 
  | 
$  | 
 7,352  | 
  | 
$  | 
 8,495  | 
  | 
  | 
 
 
 
 
 
The following table shows information about share options and options which have a nominal exercise price (similar to restricted stock units (RSUs)) granted: 
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 | 
 | 
 | 
 | 
 | 
 | 
 | 
 | 
 | 
 | 
 | 
 | 
 | 
 
  | 
  | 
  | 
Three months ended   | 
  | 
Nine months ended   | 
 
  | 
  | 
  | 
September 30,   | 
  | 
September 30,   | 
 
  | 
  | 
2020  | 
      | 
2019  | 
      | 
2020  | 
      | 
2019  | 
  | 
 
Number of options over ordinary shares granted  | 
  | 
  | 
1,882,966  | 
  | 
  | 
3,733,359  | 
  | 
  | 
14,851,182  | 
  | 
  | 
15,477,255  | 
  | 
 
Weighted average fair value of ordinary shares options  | 
  | 
$  | 
1.25  | 
  | 
$  | 
0.31  | 
  | 
$  | 
0.57  | 
  | 
$  | 
0.48  | 
  | 
 
Number of additional options with a nominal exercise price granted  | 
  | 
  | 
571,320  | 
  | 
  | 
743,292  | 
  | 
  | 
7,410,136  | 
  | 
  | 
7,700,658  | 
  | 
 
Weighted average fair value of options with a nominal exercise price   | 
  | 
$  | 
1.70  | 
  | 
  | 
0.51  | 
  | 
$  | 
0.78  | 
  | 
$  | 
0.89  | 
  | 
 
 
 
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