| Summary of the segment profit or loss | The table below is a summary of the segment profit or loss, including significant segment expenses (in thousands):  
|  |  |  |  |  |  |  |  |  |  |  |  |  
|  | Three months ended  |  | Six months ended  |  
|  | June 30,  |  | June 30,  |  
|  | 2024 |      | 2023 |  | 2024 |      | 2023 |  
| Revenue | $ |  128,231 |  | $ |  5,130 |  | $ |  133,909 |  | $ |  52,731 |  
| Less: |  |  |  |  |  |  |  |  |  |  |  |  
| Research |  |  (3,830) |  |  |  (3,499) |  |  |  (7,438) |  |  |  (5,373) |  
| CMC and Quality |  |  (14,159) |  |  |  (13,675) |  |  |  (28,933) |  |  |  (26,608) |  
| Biomarkers |  |  (2,495) |  |  |  (1,222) |  |  |  (5,286) |  |  |  (2,452) |  
| Development and Compliance |  |  (12,611) |  |  |  (8,647) |  |  |  (27,486) |  |  |  (19,037) |  
| Infrastructure management and Facilities |  |  (7,749) |  |  |  (6,126) |  |  |  (15,828) |  |  |  (13,490) |  
| Commercial planning |  |  (2,561) |  |  |  (778) |  |  |  (6,445) |  |  |  (1,426) |  
| Support functions |  |  (9,139) |  |  |  (14,074) |  |  |  (21,073) |  |  |  (28,635) |  
| Other segment expenses(a) |  |  (6,987) |  |  |  (2,017) |  |  |  (1,981) |  |  |  1,038 |  
| Total operating expenses |  |  (59,531) |  |  |  (50,038) |  |  |  (114,470) |  |  |  (95,983) |  
| Operating profit/(loss) |  |  68,700 |  |  |  (44,908) |  |  |  19,439 |  |  |  (43,252) |  
|  |  |  |  |  |  |  |  |  |  |  |  |  
| Interest income |  |  1,376 |  |  |  1,543 |  |  |  2,721 |  |  |  2,219 |  
| Interest expense |  |  (526) |  |  |  — |  |  |  (526) |  |  |  — |  
| Gain on bargain purchase |  |  — |  |  |  22,155 |  |  |  — |  |  |  22,155 |  
| Other income (expense), net |  |  497 |  |  |  501 |  |  |  436 |  |  |  (170) |  
| Income tax expense |  |  (526) |  |  |  (680) |  |  |  (1,052) |  |  |  (1,305) |  
| Segment and consolidated net profit/(loss) | $ |  69,521 |  | $ |  (21,389) |  | $ |  21,018 |  | $ |  (20,353) |   (a)Other segment expenses includes reimbursements receivable for research and development tax and expenditure credits, depreciation, amortization and share-based compensation expenses. |