Note 4 — Loss per share

The dilutive effect of 75,087,783, 47,392,118, 69,136,398 and 44,951,407 stock options for the three months ended September 30, 2017 and 2016 and the nine months ended September 30, 2017 and 2016, respectively have been excluded from the diluted loss per share calculation, because they would have an antidilutive effect on the loss per share for the period.