Quarterly report pursuant to Section 13 or 15(d)

Contingencies and commitments - Clinical Trials and Contract Manufacturing Commitments (Details)

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Contingencies and commitments - Clinical Trials and Contract Manufacturing Commitments (Details) - Clinical trials and contract manufacturing commitments - USD ($)
$ in Thousands
9 Months Ended
Sep. 30, 2017
Sep. 30, 2016
Contingencies and commitments    
Other commitments $ 74,240  
Other commitments, due within one year 34,163  
Other commitments, due in one to three years 21,364  
Other commitments, due in three to five years 17,535  
Other commitments, due after five years 1,178  
Subcontract costs $ 29,587 $ 15,908