Annual report pursuant to Section 13 and 15(d)

CONSOLIDATED STATEMENTS OF CHANGE IN EQUITY

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CONSOLIDATED STATEMENTS OF CHANGE IN EQUITY - USD ($)
$ in Thousands
Common stock
January Offering
Common stock
June Offering
Common stock
Over Allotment January
Common stock
Over Allotment June
Common stock
Additional paid in capital
January Offering
Additional paid in capital
June Offering
Additional paid in capital
Over Allotment January
Additional paid in capital
Over Allotment June
Additional paid in capital
Accumulated other comprehensive loss
Accumulated deficit
January Offering
June Offering
Over Allotment January
Over Allotment June
Total
Balance at the beginning of the period, shares at Dec. 31, 2018         627,454,270                        
Balance at the beginning of the period at Dec. 31, 2018         $ 939         $ 574,208 $ (9,763) $ (318,499)         $ 246,885
Increase (Decrease) in Stockholders' Equity                                  
Issuance of shares upon exercise of stock options         $ 4         362             $ 366
Issuance of shares upon exercise of stock options (in shares)         3,549,298                       3,549,298
Other comprehensive loss                     2,499           $ 2,499
Share-based compensation expense                   11,053             11,053
Net loss                       (137,165)         (137,165)
Balance at the end of the period at Dec. 31, 2019         $ 943         585,623 (7,264) (455,664)         123,638
Balance at the end of the period, shares at Dec. 31, 2019         631,003,568                        
Increase (Decrease) in Stockholders' Equity                                  
Issuance of shares upon exercise of stock options         $ 14         5,649             $ 5,663
Issuance of shares upon exercise of stock options (in shares)         11,401,390                       11,401,390
Issuance of shares upon completion of public offering, net of issuance costs $ 165 $ 155 $ 24 $ 24   $ 78,451 $ 209,831 $ 11,914 $ 33,824       $ 78,616 $ 209,986 $ 11,938 $ 33,848  
Issuance of shares upon completion of public offering, net of issuance costs (in shares) 126,000,000 123,000,000 18,900,000 18,450,000                          
Other comprehensive loss                     (2,784)           $ (2,784)
Share-based compensation expense                   10,414             10,414
Net loss                       (130,092)         (130,092)
Balance at the end of the period at Dec. 31, 2020         $ 1,325         935,706 (10,048) (585,756)         $ 341,227
Balance at the end of the period, shares at Dec. 31, 2020         928,754,958                       928,754,958
Increase (Decrease) in Stockholders' Equity                                  
Issuance of shares upon exercise of stock options         $ 8         751             $ 759
Issuance of shares upon exercise of stock options (in shares)         5,723,646                       5,723,646
Issuance of shares upon completion of public offering, net of issuance costs (in shares)         3,069,330                        
Issue of shares under At The Market sales agreement, net of commission and expenses         $ 4         2,525             $ 2,529
Issue of shares under At The Market sales agreement, net of commission and expenses, shares         3,069,330                        
Other comprehensive loss                     (1,094)           (1,094)
Share-based compensation expense                   20,629             20,629
Net loss                       (158,090)         (158,090)
Balance at the end of the period at Dec. 31, 2021         $ 1,337         $ 959,611 $ (11,142) $ (743,846)         $ 205,960
Balance at the end of the period, shares at Dec. 31, 2021         937,547,934                       937,547,934