Annual report pursuant to Section 13 and 15(d)

Contingencies and commitments - Collaborations and License Agreements (Details)

v3.22.0.1
Contingencies and commitments - Collaborations and License Agreements (Details) - USD ($)
 1 Months Ended 12 Months Ended
Jan. 13, 2020
Aug. 26, 2019
Jun. 16, 2016
Jun. 30, 2019
Feb. 29, 2016
Nov. 30, 2015
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2012
Sep. 26, 2016
MD Anderson Strategic Alliance                          
Collaboration and License Agreement                          
Upfront license fees                     $ 3,412,000    
License agreement | Universal Cells, Inc.                          
Collaboration and License Agreement                          
Potential milestone payments             $ 37,600,000            
Milestone payments one accrued but not yet paid             800,000            
Milestone payments two accrued but not yet paid             $ 500,000            
Upfront license and start-up fees           $ 2,500,000              
Milestone payments         $ 3,000,000         $ 200,000 $ 900,000    
License agreement | ThermoFisher                          
Collaboration and License Agreement                          
Upfront license fees                       $ 1,000,000  
Minimum annual royalties as a percentage of prior year running royalties (as a percent)             50.00%            
Supply contract agreement period (in years)     5 years                    
License agreement | MD Anderson Strategic Alliance                          
Collaboration and License Agreement                          
Milestone payments             $ 454,000 $ 3,549,000   $ 2,326,000      
License agreement | MD Anderson Strategic Alliance | Minimum                          
Collaboration and License Agreement                          
Potential milestone payments                         $ 19,644,000
License agreement | Noile Immune Biotech Inc.                          
Collaboration and License Agreement                          
Upfront license fees   $ 2,500,000                      
License agreement | Noile Immune Biotech Inc. | Maximum                          
Collaboration and License Agreement                          
Potential milestone payments             $ 312,000,000            
Astellas Collaboration Agreement | Maximum                          
Collaboration and License Agreement                          
Milestone payments $ 552,500,000                        
Research and development | Alpine Immune Sciences Inc.                          
Collaboration and License Agreement                          
Upfront license fees       $ 2,000,000         $ 2,000,000        
Research and development | Alpine Immune Sciences Inc. | Maximum                          
Collaboration and License Agreement                          
Potential milestone payments       $ 288,000,000                  
Development milestone per product developed unilaterally | Astellas Collaboration Agreement | Maximum                          
Collaboration and License Agreement                          
Potential milestone payments 147,500,000                        
Sales milestone for products developed unilaterally | Astellas Collaboration Agreement | Maximum                          
Collaboration and License Agreement                          
Potential milestone payments $ 110,000,000