Annual report pursuant to Section 13 and 15(d)

Summary of Significant Accounting Policies - Research and Development Expenditure (Details)

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Summary of Significant Accounting Policies - Research and Development Expenditure (Details) - USD ($)
12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Summary of Significant Accounting Policies      
Acquired in-process R&D expensed $ 2,316,000 $ 562,000 $ 889,000
Research and Development Asset Acquired Other than through Business Combination, Writeoff, Statement of Income or Comprehensive Income [Extensible Enumeration] Research and Development Expense Research and Development Expense Research and Development Expense
Reimbursement of Research and Development Tax and Expenditure Credit $ 30,226,000 $ 34,082,000 $ 19,442,000