Annual report pursuant to Section 13 and 15(d)

Contingencies and commitments - Universal Cells Research, Collaboration and License Agreement and Co-development and Co-commercialization agreement (Details)

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Contingencies and commitments - Universal Cells Research, Collaboration and License Agreement and Co-development and Co-commercialization agreement (Details) - Collaboration and license agreement - Universal Cells, Inc. - USD ($)
 1 Months Ended 12 Months Ended
Feb. 29, 2016
Nov. 30, 2015
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2022
Contingencies and commitments          
Upfront license and start-up fees   $ 2,500,000      
Milestone payments $ 3,000,000   $ 200,000 $ 900,000  
First milestone payment         $ 500,000
Second milestone payment         600,000
Third milestone payment         400,000
Maximum          
Contingencies and commitments          
Milestone payment accrued but not yet paid         $ 1,800,000