Annual report pursuant to Section 13 and 15(d)

Share-based compensation - Share-based Compensation Expense (Details)

v3.10.0.1
Share-based compensation - Share-based Compensation Expense (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Total share-based compensation expense included in the consolidated statements of operations      
Total share-based compensation expense $ 16,202 $ 10,804 $ 8,821
Research and development      
Total share-based compensation expense included in the consolidated statements of operations      
Total share-based compensation expense 8,340 5,268 4,185
General and administrative      
Total share-based compensation expense included in the consolidated statements of operations      
Total share-based compensation expense $ 7,862 $ 5,536 $ 4,636