Annual report pursuant to Section 13 and 15(d)

Geographic information - Operations by Geographic Area - Long-lived Assets (Details)

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Geographic information - Operations by Geographic Area - Long-lived Assets (Details) - USD ($)
Dec. 31, 2018
Dec. 31, 2017
Operations by Geographic Area    
Long-lived assets $ 36,118,000 $ 40,679,000
Clinical materials 3,953,000 4,695,000
U.K.    
Operations by Geographic Area    
Long-lived assets 18,828,000 22,786,000
U.S.    
Operations by Geographic Area    
Long-lived assets $ 17,290,000 $ 17,893,000