Quarterly report pursuant to Section 13 or 15(d)

Share-based compensation - Share-based Compensation Expense (Details)

v3.10.0.1
Share-based compensation - Share-based Compensation Expense (Details) - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended
Jun. 30, 2018
Jun. 30, 2017
Jun. 30, 2018
Jun. 30, 2017
Total share-based compensation expense included in the consolidated statements of operations        
Total share-based compensation expense $ 4,079 $ 2,072 $ 8,411 $ 4,757
Research and development        
Total share-based compensation expense included in the consolidated statements of operations        
Total share-based compensation expense 2,071 871 4,285 2,229
General and administrative        
Total share-based compensation expense included in the consolidated statements of operations        
Total share-based compensation expense $ 2,008 $ 1,201 $ 4,126 $ 2,528