| Share-based compensation | Note 12 — Share-based compensation The following table shows the total share-based compensation expense included in the unaudited consolidated statements of operations (in thousands): 
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  
|  |  |  | Three months ended  |  | Nine months ended  |  |  
|  |  |  | September 30,  |  | September 30,  |  |  
|  |      | 2019 |      | 2018 |      | 2019 |      | 2018 |  |  |  
| Research and development |  | $ |  144 |  | $ |  2,053 |  | $ |  2,951 |  | $ |  6,338 |  |  |  
| General and administrative |  |   |  1,676 |  |   |  1,989 |  |   |  5,544 |  |  |  6,115 |  |  |  
|  |  | $ |  1,820 |  | $ |  4,042 |  | $ |  8,495 |  | $ |  12,453 |  |  |   The following table shows information about share options and options which have a nominal exercise price (similar to restricted stock units (RSUs)) granted: 
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  
|  |  |  | Three months ended  |  | Nine months ended  |  
|  |  |  | September 30,  |  | September 30,  |  
|  |  | 2019 |      | 2018 |      | 2019 |      | 2018 |  |  
| Number of options over ordinary shares granted |  |  | 3,733,359 |  |  | 757,273 |  |  | 15,477,255 |  |  | 12,187,614 |  |  
| Weighted average fair value of ordinary shares options |  | $ | 0.31 |  | $ | 1.09 |  | $ | 0.48 |  | $ | 0.82 |  |  
| Number of additional options with a nominal exercise price granted |  |  | 743,292 |  |  | 1,259,760 |  |  | 7,700,658 |  |  | 7,966,716 |  |  
| Weighted average fair value of options with a nominal exercise price  |  | $ | 0.51 |  | $ | 1.67 |  | $ | 0.89 |  | $ | 1.40 |  |   |