Alpine Immune Sciences

Working with Alpine Immune Sciences to Develop Next-Generation SPEAR T-cells

Adaptimmune has a collaboration and license agreement with Alpine Immune Sciences, Inc., to develop next-generation SPEAR T-cell products that incorporate Alpine’s secreted and transmembrane immunomodulatory protein (termed SIP™ and TIP™) technology. This collaboration will further enhance our efforts to design and develop next-generation SPEAR T-cell therapies.

TIPs and SIPs can be integrated into cell-based immunotherapies providing local delivery of efficacious agents. Alpine and Adaptimmune will collaborate on a specified number of programs to develop SIP and TIP candidates with tailored affinities and modulatory activities that may enhance the anti-tumor responses seen with Adaptimmune’s SPEAR T-cells.

You can read the press release issued in May 2019 announcing the agreement.