Pipeline

Clinical Pipeline

Clinical Pipeline

Worldwide, cancer is a leading cause of death and is characterized by the uncontrolled growth of abnormal cells that have the ability to evade the immune system. Our latestage pipeline includes various SPEAR T-cell therapies in clinical trials across multiple solid tumors.

Afamitresgene autoleucel or “afami-cel” (formerly ADP-A2M4) is our first-generation TCR T-cell therapy targeting MAGE-A4. We began rolling submission of a BLA for afami-cel for the treatment of people with synovial sarcoma in late 2022 and aim to complete the submission in Q4 2023. We are also developing next-generation cell therapies and our first clinical candidate is ADP-A2M4CD8, currently being evaluated in the SURPASS family of trials, being investigated in the SURPASS and SURPASS-2 trials. Recently, we closed the Phase 1 ADP-A2AFP trial for people with liver cancer and will continue to focus development on new cell therapies for this disease.

Our Clinical Pipeline

Adaptimmune is developing an industry-leading T-cell therapy pipeline in solid tumors, and has a deep pipeline of identified and proprietary targets for further product development.

Our Clinical Pipeline

Afamitresgene autoleucel “afami-cel”

Afamitresgene autoleucel (afami-cel; formerly ADP-A2M4) is directed to a member of the MAGE family of cancer testis antigen expressed in many solid tumor cell types.

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ADP-A2M4CD8

Our first “next-generation therapy” is the ADP-A2M4CD8 SPEAR T-cell therapy. Unlike the ADP-A2M4CD8 SPEAR T-cells therapy, these cells also express the CD8α co-receptor alongside the engineered TCR that targets MAGE-A4.

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ADP-A2AFP

Our ADP-A2AFP product is being used to treat patients with hepatocellular carcinoma (liver cancer).

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