Pipeline

Overview

Overview

Industry leading TCR pipeline targeting solid tumors

Cancer is a leading cause of death worldwide and is characterized by the uncontrolled growth of abnormal cells whose ability to evade the immune system is key. Adaptimmune’s affinity enhanced T-cell therapies work with the immune system to improve detection and targeting of cancer cells, resulting in the destruction of those cancer cells. We believe that the unique potential of immunotherapy will revolutionize the treatment of oncology in the future and Adaptimmune is at the forefront of immunotherapy development. 

SPEAR® T-cell therapies targeting MAGE-A4, and AFP are progressing through clinical studies in multiple solid tumors. The clinical studies for SPEAR® T-cell therapies targeting MAGE-A10 have been closed.

Our Pipeline

Adaptimmune is developing an industry-leading T-cell therapy pipeline in solid tumors, and has a deep pipeline of identified and proprietary targets for further product development.

Target Trial Indications Phase 1 Phase 2/3
MAGE-A4 SPEARHEAD‑1 (ADP‑A2M4) Synovial Sarcoma MRCLS
Phase 1 Phase complete
Phase 2/3 Phase in progress
SURPASS (ADP‑A2M4CD8) Multiple solid tumors**
Phase 1 Phase in progress
Phase 2/3 Phase not started
Phase 1 trial (ADP‑A2M4) Multiple solid tumors** info
Phase 1 Phase in progress
Phase 2/3 Phase not started
Radiation sub‑study* (ADP‑A2M4) Multiple solid tumors**
Phase 1 Phase in progress
Phase 2/3 Phase not started
AFP Phase 1 trial (ADP‑A2AFP) Hepatocellular carcinoma
Phase 1 Phase in progress
Phase 2/3 Phase not started
MAGE-A10 Phase 1 trial (ADP‑A2M10) NSCLC Melanoma Bladder Head and Neck
Phase 1 Phase in progress
Phase 2/3 Phase not started

*Site specific protocol amendment with MD Anderson Cancer Center

**Bladder, Melanoma, Head & Neck, Ovarian, NSCLC, Esophageal, Gastric, Synovial sarcoma, MRCLS

ADP-A2M4

The ADP-A2M4 (MAGE-A4) SPEAR T-cell therapy is directed to a member of the MAGE family of cancer testis antigen expressed in many solid tumor cell types.

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ADP-A2M4CD8

Our first “next-generation therapy” is the ADP-A2M4CD8 SPEAR T-cell therapy. Unlike the ADP-A2M4CD8 SPEAR T-cells therapy, these cells also express the CD8α co-receptor alongside the engineered TCR that targets MAGE-A4.

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ADP-A2AFP

Our ADP-A2AFP product  is being used to treat patients with hepatocellular carcinoma (liver cancer).

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ADP-A2M10

The ADP-A2M10 (MAGE-A10) T-cell therapy is directed to a member of the MAGE family of cancer-testis antigens expressed in several solid tumor cell types.

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