Taking Part in Our Clinical Trials

How Do I Know if I Can Take Part?

How Do I Know if I Can Take Part?

You may be able to take part in one of our clinical trials if: 

  • You have a certain type of cancer.
  • The cancer cells have a specific protein that SPEAR T-cells can recognize. This is tested using a small sample (biopsy) of the cancer. For many people, the testing could be done from a biopsy they have had in the past.
  • Your own cells have a specific protein that the SPEAR T-cells need to help them recognize the cancer cells. This is detected by a blood test.

What Will Happen If You Take Part in One of Our Clinical Trials?

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SPEAR T-cells are not suitable for everyone. You will have a blood test and your tumor will be tested to see if you can receive SPEAR T-cells.

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If you are able to participate, some of your own T-cells will be collected from your blood. This process is called apheresis or leukapheresis. It will take a few hours at the hospital to collect your cells. These T-cells will be used to make your SPEAR T-cells

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Your T-cells will be sent to the manufacturing site, where your SPEAR T-cells are made. This process takes about a month.

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About 1 week before you receive your SPEAR T-cells, you will go to the hospital to receive chemotherapy. This is done to make room in your body for the new SPEAR T-cells.

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You will receive your SPEAR T-cells at the hospital. They are given through an IV line. It is a one-time dose. Your study doctor will decide how long you need to stay in the hospital for monitoring. For many patients, it is about 1 week, but maybe longer.

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After you receive your SPEAR T-cells, you will see your study doctor regularly for check-ups and to monitor the cancer.

What do I do next?

Please talk to your doctor or nurse if you would like more information or think you would like to take part in a clinical trial. You and your doctor will make the decision if a clinical trial is right for you.

Where Do I Go to Find Out More?

To learn more about Adaptimmune’s trials you can visit our Clinical Trials page or:

If you have enquiries, please contact patients@adaptimmune.com

Useful Words


A type of treatment that boosts your body's own ability to attack and destroy cancer cells.

SPEAR T-cells

An investigational immunotherapy made from T-cells (a type of white blood cells), which are a part of your body's own immune system. SPEAR T-cells are designed to seek out cancer cells.


A procedure used to remove white blood cells. Blood is taken from your vein and passed through a machine, which removes the white blood cells. The rest of the blood is returned to your body.


A treatment that kills cells or stops them from dividing. In Adaptimmune's trials, chemotherapy is used to reduce the number of regular T-cells in your body, to make room for the SPEAR T-cells.

IV line

An IV (intravenous) line is a flexible plastic tube that goes through the skin into your bloodstream. It is used to take blood and to give you treatments into the bloodstream.

Our Clinical Trials

We are conducting clinical trials with our three SPEAR T-cell therapies (ADP-A2M4, ADP-A2AFP, and ADP-A2M4CD8) in ten cancers. The purpose of this section is to serve as an introduction for patients who might be interested in our current trials.

View Clinical Trials