Taking Part in our Clinical Trials

How do I know if I can take part?

You may be able to take part in one of our clinical trials if:

You have a certain type of cancer.
The cancer cells have a specific protein that SPEAR T-cells can recognize. This is tested using a small sample (biopsy) of the cancer. For many people, the testing could be done from a biopsy they have had in the past.
Your own cells have a specific protein that the SPEAR T-cells need to help them recognize the cancer cells. This is detected by a blood test.

What will happen if you take part in one of our clinical trials?

1

SPEAR T-cells are not suitable for everyone. You will have a blood test and your tumor will be tested to see if you can receive SPEAR T-cells.

2

If you are able to participate, some of your own T-cells will be collected from your blood. This process is called apheresis or leukapheresis. It will take a few hours at the hospital to collect your cells. These T-cells will be used to make your SPEAR T-cells.

3

Your T-cells will be sent to the manufacturing site, where your SPEAR T-cells are made. This process takes about a month.

4

About 1 week before you receive your SPEAR T-cells, you will go to the hospital to receive chemotherapy. This is done to make room in your body for the new SPEAR T-cells.

5

You will receive your SPEAR T-cells at the hospital. They are given through an IV line. It is a one-time dose. Your study doctor will decide how long you need to stay in the hospital for monitoring. For many patients it is about 1 week, but may be longer.

6

After you receive your SPEAR T-cells, you will see your study doctor regularly for check-ups and to monitor the cancer.

Where do I go to find out more?

To learn more about Adaptimmune’s trials you can:

Visit the Cancer Information page for more information on the types of cancer we are working on.
Go to ClinicalTrials.gov, a database of clinical trials across the world. To see a list of all our trials, enter "Adaptimmune" in the search box for other terms.
Visit the Technology section to learn about our industry leading technology platform
Download the "Adaptimmune Clinical Trials - What you need to know" leaflet as a reference

What do I do next?

Please talk to your doctor or nurse if you would like more information or think you would like to take part in a clinical trial. You and your doctor will make the decision if a clinical trial is right for you.