ADP-A2M4CD8

Overview

Overview

Our ADP-A2M4CD8 SPEAR T-cell therapy is our first "next-generation" therapy and is directed to MAGE-A4, a member of the MAGE family of cancer-testis antigens expressed in a number of solid tumor types. What differentiates this therapy from our ADP-A2M4 SPEAR T-cells is that these cells also express the CD8α co-receptor alongside the engineered TCR that targets MAGE-A4. Preclinical data indicate that co-expression of CD8α may broaden the immune response against solid tumors and increase antitumor activity by leveraging CD4+ cells into CD8+ killer or cytotoxic T‑cells while retaining their CD4+ helper function.

Our Trials

pipeline

Cancer indications in the SURPASS Trial

Synovial Sarcoma

Synovial Sarcoma

Soft tissue sarcomas can develop from soft tissues like fat, muscle, nerves, fibrous tissues, blood vessels, or deep skin tissues.

Myxoid/Round Cell Liposarcoma (MRCLS)

Myxoid/Round Cell Liposarcoma (MRCLS)

Soft tissue sarcomas can develop from soft tissues like fat, muscle, nerves, fibrous tissues, blood vessels, or deep skin tissues.

Melanoma

Melanoma

Melanoma is a cancer that begins in specific skin cells called melanocytes.

Advanced Urothelial Cancer

Advanced Urothelial Cancer

Urothelial carcinoma, also known as transitional cell carcinoma (TCC), is the most common type of bladder cancer.

Ovarian

Ovarian

Ovarian cancer begins in the ovaries, which are made up of 3 main kinds of cells. Each type of cell can develop into a different type of tumor.

Non-Small Cell Lung Cancer (NSCLC)

Non-Small Cell Lung Cancer (NSCLC)

Non-small cell lung cancer or NSCLC is the most common type of lung cancer, representing about 85% of lung cancers.

Head and Neck

Head and Neck

Head and neck cancer arises in the epithelium of the paranasal sinuses, nasopharynx, oropharynx, oral cavity, hypopharynx and larynx.

Gastric Cancer

Gastric Cancer

Stomach cancers, or gastric cancers, tend to develop slowly over many years.

Esophageal

Esophageal

Cancer of the esophagus starts in the inner layer (the mucosa) and grows outward (through the submucosa and the muscle layer). Since two types of cells can line the esophagus, there are two main types of esophageal cancer, squamous cell carcinoma and adenocarcinoma. Esophageal cancer is more common among men than among women.

Bladder

Bladder

Urothelial carcinoma, also known as transitional cell carcinoma (TCC), is the most common type of bladder cancer.

Esophagogastric Junction (EGJ)

Esophagogastric Junction (EGJ)

Adenocarcinomas that start at the area where the esophagus joins the stomach (the GE junction, which includes about the first 2 inches (5 cm) of the stomach), tend to behave like cancers in the esophagus and are treated like them, as well.

Publications

Review our findings and publications.

Latest News

An IND for our SURPASS trial (ADP-A2M4CD8) was filed in April 2019. The SURPASS trial is the first next-generation approach in the clinic in multiple solid tumors set to initiate later this year.

View Press Release