Overview

Industry Leading TCR Pipeline Targeting Solid Tumors

Cancer is a leading cause of death worldwide and is characterized by the uncontrolled growth of abnormal cells whose ability to evade the immune system is key. Adaptimmune’s affinity enhanced T-cell therapies work with the immune system to improve detection and targeting of cancer cells, resulting in destruction of those cancer cells. We believe that the unique potential of immunotherapy will revolutionize the treatment of oncology in the future and Adaptimmune is at the forefront of immunotherapy development.

SPEAR® T-cell therapies targeting MAGE-A10, MAGE-A4, and AFP are progressing through clinical studies in multiple solid tumors.

The foundation of our TCR therapies is the work we did with NY-ESO SPEAR T-cells, which we transitioned to GSK in 2018, showing responses in two solid tumors and treating more than 90 patients in six different indications.

Our Pipeline

Adaptimmune is developing an industry leading TCR pipeline in solid tumors, and has a deep pipeline of identified and proprietary targets for further TCR development.

SPEAR
T-cell
Target Indications Target dose (Cohort) 5 BN+
(expansion)
Registration
studies
100 M (1) 1 BN (2) 5 BN (3)
ADP-A2M10 MAGE-A10 Non-small cell lung cancer (NSCLC)
100 M (1) Phase complete
1 BN (2) Phase complete
5 BN (3) Phase complete
5 BN+ (expansion) Phase in progress
Registration studies Phase not started
Triple Tumor (Bladder, Melanoma, Head & Neck)
100 M (1) Phase complete
1 BN (2) Phase complete
5 BN (3) Phase complete
5 BN+ (expansion) Phase in progress
Registration studies Phase not started
ADP-A2M4 MAGE-A4 Multiple Solid Tumor (Bladder, Melanoma, Head & Neck, Ovarian, NSCLC, Esophegeal, Gastric, Synovial Sarcoma, MRCLS)
100 M (1) Phase complete
1 BN (2) Phase complete
5 BN (3) Phase complete
5 BN+ (expansion) Phase in progress
Registration studies Phase not started
ADP-A2AFP AFP Hepatocellular carcinoma
100 M (1) Phase complete
1 BN (2) Phase in progress
5 BN (3) Phase not started
5 BN+ (expansion) Phase not started
Registration studies Phase not started
Additional SPEAR T-Cell Candidates
Multiple targets/Multiple Indications